Johns Hopkins Medicine researchers say they have identified molecular pathways controlled by the protein RhoA in club cells — a specialized population of epithelial cells that exclusively lines the inner and outer surfaces of the lung’s small airways, with known roles in immune regulation and airway repair — during allergen-induced airway inflammation. Through a series of translational mouse and cell culture experiments, the research team has demonstrated how RhoA can be selectively targeted to potentially prevent asthma-related complications.
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