People with asthma often experience a worsening of symptoms after eating, but the underlying mechanisms are poorly understood. Dysregulated type 2 immunity in the lung is a known driver of asthma, and ILC2 immune cells have a key role. As food intake is followed by an increase in parasympathetic neurotransmitter release (such as acetylcholine (ACh)), including in the lung, Chen et al. investigated whether postprandial parasympathetic stimulation of type 2 immunity might underlie the food-related exacerbation of asthma-like symptoms in mice.
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